HCID 15523989, compound → HCID 11123362, compound

Participants

Reaction Conditions

Reaction Steps

A solution of the title compound of step (J) (0.77 g, 1.54 mmol) in MeOH (16 mL) and CH2Cl2 (3 mL) cooled at 0° C. was purged with argon for 20 minutes. To this solution 370 μL of NaOMe (25% w/w in MeOH) was added dropwise. After addition, the mixture was stirred at 0° C. for 15 minutes before being quenched with sat. aqueous NH4Cl (20 mL). The mixture was extracted with EtOAc (200 mL). The separated aqueous phase was back-extracted with EtOAc (50 mL). The combined EtOAc was washed with sat. aqueous NH4Cl, H2O, brine, dried (MgSO4), filtered, concentrated and dried in vacuo to give 0.736 g of the title compound of this step as a white foam which was used in the next reaction step without further purification.

Provenance & Evidence