1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 21997034, compound

Participants

Reaction Steps

A mixture of 2-[(4-methoxybenzenesulfonyl)methyl]-5-(4-methoxybenzenesulfonyl)-pentanoic acid (0.5 g, 1.1 mmol), benzylhydroxylamine hydrochloride (0.21 g, 1.3 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.42 g, 2.2 mmol), and tetrahydrofuran/water (1/1, 10 mL) is stirred at ambient temperature overnight. The mixture is transferred to ethyl acetate which is extracted with aqueous 10% hydrochloric acid, distilled water, aqueous sodium bicarbonate, and brine. The organic phase is concentrated in vacuo to yield the title compound as a white solid.

Provenance & Evidence