HCID 21996975, compound → HCID 21996970, compound

HRID 1978236Notes

Reaction equation

HRID 1978236 reaction equation
BrC1C=CC(O)=C(C=1)C(C1C=CC(C)=CC=1)=O.[Br:18][C:19]1[C:20]([CH3:36])=[CH:21][C:22]([O:34]C)=[C:23]([CH:33]=1)[C:24]([C:26]1[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=1)=[O:25]>>[Br:18][C:19]1[C:20]([CH3:36])=[CH:21][C:22]([OH:34])=[C:23]([CH:33]=1)[C:24]([C:26]1[CH:27]=[CH:28][C:29]([CH3:32])=[CH:30][CH:31]=1)=[O:25]

Participants

3

Reactant 2

HCID 21996975HCID 21996975, compound2×HCID 21996981HCID 21996981, compound2×

Product 1

HCID 21996970HCID 21996970, compound

Procedure

Employing the same general procedure as for the 5-bromo-2-hydroxy-4′-methylbenzophenone (Compound K), 319 mg (1.0 mmol) of 5-bromo-2-methoxy-4-methyl-4′-methylbenzophenone (Compound I) was converted into the title compound using 2.4 mL (2.4 mmol) of boron tribromide (1M in dichloromethane) and 10 mL of dichloromethane. Purification by flash chromatography (silica, 10% ethyl acetate in hexane) gave the title compound as a pale yellow solid.

Sources & evidence

ORD record
ord-6de7745f09114e20bd712769e7e53a65
Source dataset
uspto-grants-2001_05
Patent number
US06235923B1

Reaction notes

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