Methyl iodide → HCID 21996653, compound

Participants

Reaction Steps

NaH (60%, 0.28 g, 6.9 mmol), 33 (2.16 g, 3.0 mmol), and iodomethane (6.1 mL, 9.8 mmol) in DMF (30 mL) were combined and worked up by the method of 43. Column chromatography (7:3 hexane/EtOAc) gave 1.90 g (85%) of 53 as an oil: NMR δ 1.08-1.16 (m, 2 H), 1.38-1.50 (m, 8 H ), 2.28-2.29 (2 s, 9 H), 2.57-2.58 (2 s, 18 H), 2.63 (s, 3 H), 2.65 (s, 3 H), 3.02-3.14 (m, 8 H), 6.95 (s, 6 H); HRMS calcd. for C38H58N3O6S3 748.3487 (M+H), found. 748.3483 (M+H).

Provenance & Evidence