1,3-Dibromopropane → HCID 10642375, compound

Participants

Reaction Steps

NaH (60%, 0.34 g, 8.4 mmol), 65 (1.7 g, 7.0 mmol), and 1,3-dibromopropane (17.0 g, 84 mmol) in DMF (30 mL) were combined and worked up by the method of 43. Column chromatography (6:1 hexane/EtOAc) produced 1.82 g (80%) of 66 as an oil: NMR δ 0.79 (s, 3 H), 1.48-1.56 (m, 2 H), 2.04-2.10 (m, 2 H), 2.30 (s, 3 H), 2.60 (s, 6 H), 3.09-3.14 (m, 2 H), 3.29-3.36 (m, 4 H). Anal. (C15H24BrNO2S) C, H, N.

Provenance & Evidence