Sodium Bicarbonate → HCID 21993917, compound

Participants

Reaction Steps

To a solution of 3.699 g (7.316 mM) of 5-(tert-butyldiphenylsiloxymethyl)-2-(3-phenylpropan-1-yl)-2,3-dihydro-1H-isoindole in 50 ml of tetrahydrofuran was added 8.78 ml (8.78 mM) of 1.0N-tetrabutylammonium fluoride-tetrahydrofuran at room temperature and the mixture was stirred for 1 hour. This reaction mixture was poured in aqueous solution of sodium hydrogen carbonate and extracted with 3 portions of ethyl acetate. The pooled organic layer was dried over MgSO4 and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1 to ethyl acetate) to provide the title compound.

Provenance & Evidence