Benzyl Bromide → HCID 70246716, compound

Participants

Reaction Steps

To an acetonitrile (40 ml) solution of 4.5 g (21.0 mmol.) of trans-1-tert-butoxycarbonyl-2,5-dimethyl piperazine and 5.9 ml (42.3 mmol.) of triethylamine was added, at room temperature, 3.2 ml (26.9 mmol.) of benzyl bromide. The mixture was heated for 24 hours under reflux. The solvent was distilled off under reduced pressure. To the residue was added water. The mixture was subjected to extraction with ethyl acetate. The organic layer was washed with a saturated aqueous saline solution, which was dried over magnesium sulfate. The solvent was distilled off under reduced pressure. The residue was purified by means of a column chromatography (ethyl acetate/hexane 10%) to give the object compound as a pale yellow oily product. The yield was 5.17 g (81%).

Provenance & Evidence