HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-nitrocinnamate → Ethyl 3-(3-Aminophenyl)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-nitrocinnamate | HCID 5354248 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl 3-(3-Aminophenyl)propionate | HCID 82314 | 61% |
Reaction Steps
(E)-Ethyl 3-(3-nitrophenyl)acrylate (12.1 g, 52.9 mmol) in tetrahydrofuran (100 ml) was hydrogenated over 10% palladium-Carbon (2.80 g) at atmospheric pressure. After removal of the catalyst, the filtrate was concentrated in vacuo. The residue was chromatographed on silica gel (100 g) with hexane-ethyl acetate (3:1) to give ethyl 3-(3-aminophenyl)propionate as a yellow oil (6.21 g, 61%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235731B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-ccdd5f9aceb749079de69d25c9c3aad7 |
| Source note | uspto-grants-2001_05 |