Hydrochloride methanol → HCID 21994176, compound

HRID 1978444Notes

Reaction equation

HRID 1978444 reaction equation
[CH3:1][N:2]([CH2:17][CH:18]1[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:20][CH2:19]1)[C:3]([C:5]1[S:15][C:14]2[N:16]3[C:7](=[CH:8][N:9]=[C:10]3[CH:11]=[CH:12][CH:13]=2)[CH:6]=1)=[O:4].[ClH:33].CO>C(O)C>[ClH:33].[ClH:33].[CH3:1][N:2]([CH2:17][CH:18]1[CH2:19][CH2:20][N:21]([CH2:24][CH2:25][CH2:26][C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:22][CH2:23]1)[C:3]([C:5]1[S:15][C:14]2[N:16]3[C:7](=[CH:8][N:9]=[C:10]3[CH:11]=[CH:12][CH:13]=2)[CH:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 21993854HCID 21993854, compound

Product 1

HCID 21994176HCID 21994176, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 346.1 mg (0.77 mM) of N-methyl-N-[1-(3-phenylpropan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (4 ml) was added 2.0 ml (8.0 mM) of 4N-HCl/methanol and the mixture was stirred at room temperature for 20 minutes. The solvent was then distilled off under reduced pressure to provide the title compound.

Workup

  1. distillationThe solvent was then distilled off under reduced pressure

Sources & evidence

ORD record
ord-fa87579684654a39b41eefb71e55b1df
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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