反应详情

To a solution of 2.91 g (6.95 mM) of N-[1-(3-phenylpropan-1-yl)piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (10 ml) was added 10 ml (40 mM) of 4N-HCl/methanol at room temperature and the mixture was stirred at room temperature for several minutes. After the solvent was distilled off under reduced pressure, ethanol and diethyl ether were added to the residue. The resulting crystals were collected by filtration and rinsed with ethanol and diethyl ether to provide 3.08 g (90%) of N-[1-(3-phenylpropan-1-yl)piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride as orange-colored solid.

1. distillationAfter the solvent was distilled off under reduced pressure, ethanol and diethyl ether
2. additionwere added to the residue
3. filtrationThe resulting crystals were collected by filtration
4. washrinsed with ethanol and diethyl ether