Hydrochloric Acid → HCID 21993629, compound

Participants

Reaction Steps

To a solution of 473.3 mg (0.93 mmol.) of N-[1-[3-(3-ethoxycarbonylphenoxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (5 ml) was added, at room temperature, 2 ml (24 mmol.) of 12N hydrochloric acid. The mixture was stirred for several minutes. The reaction mixture was concentrated under reduced pressure. To the concentrate was added ethanol. The resulting crystals were collected by filtration and washed with ethanol and diethyl ether to give the object compound (425.4 mg, 79%) as orange crystals, m.p.140-145° C.

Provenance & Evidence