Sodium Iodide → HCID 21993643, compound

Participants

Reaction Steps

Benzylchloride (187 mg, 1.48 mmol) was added to a stirred solution of N-[3-(2-oxopiperazin-1-yl)propan-1-yl]-5-thia-1,8b-diazaacenaphtylene-4-carboxamide dihydrochloride (518 mg, 1.20 mmol), triethylamine (605 mg, 5.98 mmol), sodium iodide (216 mg, 1.44 mmol) and 1,8-diazabicyclo[5.4.0]undecene (366 mg, 2.41 mmol) in acetonitrile (20 ml) at room temperature. After refluxing under nitrogen for 2 days, the reaction mixture was concentrated in vacuo. The residue was dissolved in water and extracted with chloroform. The extract was washed with brine, dried over MgSO4 and concentrated in vacuo. The residue was chromatographed on silica gel (20 g) with Ethyl acetate-Methanol (8:1) to give N-[3-(4-phenylmethyl-2-oxopiperazine-1-yl)propane-1-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide as a purple amorphous powdeer (303 mg, 56%).

Provenance & Evidence