Hydrochloric Acid → N-[1-[3-(4-aminophenyl)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide trihydrochloride

Participants

Reaction Steps

Concentrated hydrochloric acid (1.5 ml) was added to N-[1-[3-(4-tert-butoxycarbonylaminophenyl)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide (350 mg, 0.656 mmol) and the mixture was stirred at room temperature for 2 hours. Ethanol was added to the mixture to give N-[1-[3-(4-aminophenyl)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide trihydrochloride as orange crystals (251 mg, 71%), which were collected by filtration and washed with ethanol.

Provenance & Evidence