Hydrochloric Acid → HCID 21995836, compound

Participants

Reaction Steps

To a solution of 7-(4-ethoxyphenyl)-N-[4-[N-methyl-N-(tetrahydropyran-4-yl)aminomethyl]phenyl]-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxamide (2.5 g) in THF (125 ml) was added at room temperature 6N hydrochloric acid (1.5 ml), and the mixture was stirred for 0.5 hour and concentrated under reduced pressure. To the mixture was added diethylether, colorless crystals were collected by filtration to give crude crystals (2.61 g), which were purified with recrystallization from 90% ethanol to give colorless crystals of 7-(4-ethoxyphenyl)-N-[4-[N-methyl-N-(tetrahydropyran-4-yl)aminomethyl]phenyl]-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxamide hydrochloride (Compound 5) (2.33 g).

Provenance & Evidence