Hydrochloric Acid → 7-(4-Trifluoromethylphenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid

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Reaction Steps

To a solution of methyl 7-(4-trifluoromethylphenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate (600 mg) in 1,2-dimethoxyethane (40 ml) was added at room temperature 6N hydrochloric acid (20 ml), and the mixture was refluxed for 22 hours, cooled to room temperature and extracted with ethyl acetate/THF. The organic layer was washed with saturated brine, dried with magnesium sulfate and concentrated under reduced pressure to give crystals, which were collected by filtration. The crystals were washed with hexane to give colorless crystals of 7-(4-trifluoromethylphenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid (439.5 mg).

Provenance & Evidence