HCID 21995750, compound → HCID 21995951, compound

Participants

Reaction Conditions

Reaction Steps

In 1,2-dimethoxyethane (20 ml) and 6N hydrochloric acid (6.7 ml) was dissolved methyl 7-[(4-butylthio)phenyl]-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate (670 mg), and the mixture was stirred at 100° C. for 16 hours, cooled to room temperature, extracted with ethyl acetate, washed with saturated brine and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated to give 7-[(4-butylthio)phenyl]-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid (620 mg).

Provenance & Evidence