HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 7-bromo-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate → 7-Bromo-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 7-bromo-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate | HCID 21995732 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 7-Bromo-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid | HCID 21995978 | 94.6% |
Reaction Steps
A solution of methyl 7-bromo-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate (700 mg) in 1,2-dimethoxyethane (15 ml) and 6N hydrochloric acid was refluxed for 18 hours and cooled to room temperature. The solvent was evaporated under reduced pressure to give colorless crystals, which were collected by filtration. The crystals were washed with water, 2-propanol and diisopropylether to give colorless crystals of 7-bromo-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid (634 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235771B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-ffd8ff269d244527b2393b0a87a33304 |
| Source note | uspto-grants-2001_05 |