Boron tribromide → 4-Bromocatechol

Participants

Reaction Steps

To a solution of boron tribromide (25 g) in dichloromethane (100 ml) was added dropwise at 0° C. a solution of 3,4-dimethoxybromobenzene (10.0 g) in dichloromethane (20 ml), and the mixture was stirred at room temperature for 15 hours and then added to ice/water to stop the reaction. The mixture was extracted with diethylether, and the organic layer was washed with saturated brine, dried with magnesium sulfate and concentrated under reduced pressure to give colorless crystals of 4-bromocathechol (8.43 g).

Provenance & Evidence