HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1978615Generated: October 28, 2026
Sodium Iodide → 1-Bromo-4-(2-methoxyethoxy)benzene
https://huagongshe.com/reaction/1978615
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | 4-Bromophenol | HCID 7808 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloroethyl methyl ether | HCID 12316 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Bromo-4-(2-methoxyethoxy)benzene | HCID 14026183 | — |
Reaction Steps
To a mixture of 4-bromophenol (15 g), sodium iodide (13.0 g) and potassium carbonate (14.4 g) in DMF (200 ml) was added at room temperature 2-chloroethylmethyl ether (9 ml), and the mixture was stirred at 80° C. for 3 days. To the mixture was added water, and the mixture was extracted with diethylether. The organic layer was washed with water and saturated brine, dried with magnesium sulfate and concentrated under reduced pressure to give orange oil of 1-bromo-4-(2-methoxyethoxy)benzene (17.44 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06235771B1 |
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| Source dataset | uspto-grants-2001_05 |
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| ORD ID | ord-f2e002814c224826b6904faf1b693641 |
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| Source note | uspto-grants-2001_05 |
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