Hydrochloric Acid → HCID 21995913, compound

Participants

Reaction Steps

To a solution of N-[4-[[N-methyl-N-(tetrahydropyran-4-yl)amino]methyl]phenyl]-7-(4-propoxyphenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxamide (17.6 g) in THF (1160 ml) was added at room temperature 6N hydrochloric acid (10 ml), and the mixture was stirred for 2 hours. Precipitated crystals were collected by filtration and washed with THF and diisopropylether to give colorless crystals, which were recrystallized from ethanol/water to give colorless crystals of N-[4-[[N-methyl-N-(tetrahydropyran-4-yl)amino]methyl]phenyl]-7-(4-propoxyphenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxamide hydrochloride (Compound 76) (13.2 g).

Provenance & Evidence