Sodium Iodide → HCID 21995745, compound

Participants

Reaction Conditions

Reaction Steps

In DMF (90 ml) was dissolved 4-bromo-3-fluorophenol (9.0 g), and to the solution were added at room temperature potassium carbonate (9.8 g), sodium iodide (7.8 g) and 2-chloroethylpropylether(7.7 ml). The mixture was stirred at 90° C. for 16 hours and cooled to room temperature. The reaction solution was poured into water, and the mixture was extracted with ethyl acetate, washed with saturated brine and dried with magnesium sulfate. Under reduced pressure, the solvent was removed, and the residue was purified with silica gel column chromatography (hexane/ethyl acetate=8/1) to give 1-bromo-2-fluoro-4-(2-propoxyethoxy)benzene (8.8 g).

Provenance & Evidence