Sodium Iodide → HCID 54239663, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-hydroxybenzofuran (1.90 g) in DMF (30 ml) were added potassium carbonate (5.09 g) and sodium iodide (5.52 g) and then was added 2-chloroethylpropylether (3.47 g), and the mixture was stirred, under nitrogen atmosphere, at 95° C. for 3 days and cooled. To the mixture was added water, and the mixture was extracted with ethyl acetate (twice). The organic layer washed with 1N sodium hydroxide solution, water and saturated brine, and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated, and the residue was purified with silica gel column chromatography to give yellow oil of 5-propoxyethoxybenzofuran (1.22 g).

Provenance & Evidence