Methyl iodide → HCID 21995814, compound

Participants

Reaction Steps

To a solution of 7-(4-butoxyphenyl)-N-[4-[N-methyl-N-(tetrahydropyran-4-yl)aminomethyl]phenyl]-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxamide (300 mg) in DMF (7 ml) was added at room temperature methyl iodide (63 μl), and the mixture was stirred for 18 hours and concentrated under reduced pressure. To the residue was added ethyl acetate, and the resulting crystals were collected by filtration and recrystallized from ethanol to give pale yellow of crystals N-[4-[[7-(4-butoxyphenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carbonyl]amino]benzyl]-N,N-dimethyltetrahydro-2H-pyran-4-aminium iodide (Compound 149) (290 mg).

Provenance & Evidence