Water → HCID 54136215, compound

Participants

Reaction Steps

Potassium thioacetate (8.4 g, 73 mmol), 2-picolyl chloride hydrochloride 1 (6.0 g, 37 mmol) and potassium carbonate (5.0 g, 37 mmol) were stirred in DMF (35 mL) at room temperature (20-22°) for 18 h. The reaction mixture was poured into water (200 mL). The resultant mixture was extracted with Et2O (2×50 mL). The combined organic phases were washed with water and brine, dried (MgSO4), filtered and concentrated to give 2-picolyl thioacetate as a pale brown liquid (5.65 g). The product was used without purification.

Provenance & Evidence