HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-3-(triphenyl phosphoranylidene)propan-2-one → 3-[4-Chloro-3-(4-chloro-3-oxobut-1-enyl)-phenyl]-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-3-(triphenyl phosphoranylidene)propan-2-one | HCID 287004 | — |
| Reactant | 2-Chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]benzaldehyde | HCID 21201225 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-[4-Chloro-3-(4-chloro-3-oxobut-1-enyl)-phenyl]-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine | HCID 86756858 | — |
Reaction Steps
4.6 g of chloroacetylmethylenetriphenylphosphorane were added to a solution of 3.3 g of 3-[4-chloro-3-formylphenyl]-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine in 100 ml of methanol, and stirring was carried out for 10 hours at room temperature. The precipitate which had separated out was isolated, washed with petroleum ether and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06239074B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-e7001cb0499d4b6fb558d98658883280 |
| Source note | uspto-grants-2001_05 |