Sodium Hydroxide → HCID 86756859, compound

HRID 1978852Notes

Reaction equation

HRID 1978852 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[NH:10][C:9]2=[O:19])=[CH:4][C:3]=1[CH:20]=[C:21]([Cl:27])[C:22]([O:24]CC)=[O:23].[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[NH:10][C:9]2=[O:19])=[CH:4][C:3]=1[CH:20]=[C:21]([C:22]([OH:24])=[O:23])[Cl:27]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86756860HCID 86756860, compound

Product 1

HCID 86756859HCID 86756859, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.4 g of 3-[4-chloro-3-(2-chloro-2-ethoxycarbonylethenyl)-phenyl]-2,4-dioxo-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine were added to a suspension of 0.8 g of sodium hydroxide in 100 ml of ethanol and stirring was carried out for 20 hours at room temperature. The reaction mixture was evaporated down, the residue was taken up in water and the solution was brought to pH 3 with 10% strength HCl. The precipitate which had separated out was isolated, washed with water and petroleum ether and dried under reduced pressure.

Workup

  1. customThe reaction mixture was evaporated down
  2. customThe precipitate which had separated out
  3. customwas isolated
  4. washwashed with water and petroleum ether
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-c35c0d730bd64e3e89b72f45f00730c3
Source dataset
uspto-grants-2001_05
Patent number
US06239074B1

Reaction notes

Loading…