Allyltributylstannane → HCID 70097299, compound

Participants

Reaction Conditions

Reaction Steps

Argon was passed through a solution of tert-butyl 3-(2-trifluoromethylsulfonyloxy-5-methoxyphenyl)propionate (15 g, 39 mmol), allyltributyl tin (15.8 mL, 51 mmol), and lithium chloride (2.1 g, 51 mmol) in DMF (120 mL) for 10 min, and bis(triphenylphosphine)palladium dchloride (1.5 g, 2.2 mmol) was added. The reaction mixture was heated at 95° C. for 1.5 h and evaporated. The residue was partitioned between 10% KF aquoues solution and ether. The combined extracts were dried and evaporated to give the titled compound (18.5 g).

Provenance & Evidence