Tetrahydrofuran → HCID 21202063, compound

Participants

Reaction Steps

To a solution of tert-butyl 3-(2-propeny-5-methoxyphenyl)propionate (7.2 g, 26 mmol) in THF (60 mL) and H2O (30 mL) were added NaO4 (9.8 g, 46 nmmol) and 4% osmium tetroxide (1 mL). After stirring at RT, the mixture was filtered and the filtrate was diluted with ether. The combined extracts were dried and evaporated to give the crude product which was flash chromatographed to give the titled compound (3.0 g; 43% yield).

Provenance & Evidence