HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Anthranilic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 14296407 | HCID 14296407 | — |
| Product | Anthranilic Acid | HCID 227 | — |
| Product | Butanoic acid, 4-chloro-4-oxo-, ethyl ester | HCID 84648 | — |
Reaction Steps
In the same way as in Example 15, the intermediate 2 is reacted with 2-(3-ethoxycarbonylpropanoylamino)benzoic acid obtained by reaction of anthranilic acid with ethyl 3-chlorocarbonylpropanoate in CH2Cl2 in the presence of triethylamine, according to a method adapted from Tetrahedron Lett. 50 (1994) 34, 10331. The product is purified by flash chromatography on a column of silica, eluting with the solvent C/A30.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06239130B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-98354a3d052b4a5d9ccdfd8aa68d5ce4 |
| Source note | uspto-grants-2001_05 |