Water → N-(4-Chlorobenzyl)-7-methyl-2-(4-morpholinyl-carbonyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide

Participants

Reaction Steps

To a solution of N-(4-chlorobenzyl)-4-hydroxy-2-(4-morpholinylcarbonyl)thieno[2,3-b]pyridine-5-carboxamide (0.527 g) from Example No. 47 in DMF (10 mL) is added potassium carbonate (0.337 g) followed by iodomethane (0.11 mL). The reaction mixture is stirred at room temperature for 1 h. The reaction mixture is then poured into water (25 mL). The resulting off-white solid is filtered off and recrystallized from acetonitrile to yield 0.448 g (82%) of the title compound as a white solid.

Provenance & Evidence