3-Bromo-2-methyl-1-propene → 5-Carboxy-2-(2-methyl-1-buten-4-yl)indole

HRID 1978990Notes

Reaction equation

HRID 1978990 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([CH2:13][CH3:14])=[CH:7]2)([OH:3])=[O:2].Br[CH2:16][C:17](C)=[CH2:18]>>[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([CH2:13][CH2:14][C:17]([CH3:18])=[CH2:16])=[CH:7]2)([OH:3])=[O:2]

Participants

3

Reactant 2

HCID 3577853-Bromo-2-methyl-1-propeneHCID 227083285-Carboxy-2-ethylindole

Product 1

HCID 187616275-Carboxy-2-(2-methyl-1-buten-4-yl)indole

Procedure

Refer to 36a) using 3-bromo-2-methylpropene as the alkylating agent.

Sources & evidence

ORD record
ord-a33bcad60f664b999f76059068620535
Source dataset
uspto-grants-2001_05
Patent number
US06239161B1

Reaction notes

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