Methanol → HCID 15390785, compound

HRID 1979002Notes

Reaction equation

HRID 1979002 reaction equation
[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:20])[CH2:11][C:12]2[CH:17]=[CH:16][C:15](SC)=[CH:14][CH:13]=2)=[CH:6][CH:5]=1.O[O:23][S:24]([O-:26])=O.[K+].[CH3:28]O>O>[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:5]=[CH:6][C:7]([C:10](=[O:20])[CH2:11][C:12]2[CH:17]=[CH:16][C:15]([S:24]([CH3:28])(=[O:26])=[O:23])=[CH:14][CH:13]=2)=[CH:8][CH:9]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 15390784HCID 15390784, compoundHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 15390785HCID 15390785, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 7.10 g of 4-(2-(4-methylthiophenyl)-1-oxo-ethyl)benzoic acid methyl ester in MeOH (100 mL) was added oxone (21.0 g) in H2O (20.0 mL) at 0° C. After a few hours at r.t., the reaction mixture was extracted with EtOAc and H2O to afford after flash chromatography (50 to 100% EtOAc in hexane), the title product as a white solid (3.20 g).

Workup

  1. waitAfter a few hours at r.t.
  2. extractionthe reaction mixture was extracted with EtOAc and H2O
  3. customto afford after flash chromatography (50 to 100% EtOAc in hexane)

Sources & evidence

ORD record
ord-6e24084e44754713b7111354c3c84637
Source dataset
uspto-grants-2001_05
Patent number
US06239173B1

Reaction notes

Loading…