HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 1-Methylpiperidine-3-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1-methylpiperidine-3-carboxylic Acid | HCID 2736937 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Methylpiperidine-3-carbonyl chloride | HCID 20026018 | — |
Reaction Steps
The hydrochloride salt of (±)-N-methylnipecotic acid (1.0 g) was suspended in dichloromethane (25 ml) and stirred at room temperature for 2 h with oxalyl chloride (0.58 ml) and DMF (1 drop). The solvent was then evaporated to yield the hydrochloride salt of N-methylnipecotyl chloride as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06239175B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-2eb0199682ca473c95fae49870026299 |
| Source note | uspto-grants-2001_05 |