HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3-bromophenoxy)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Acetic acid, 2-(3-bromophenoxy)-, methyl ester | HCID 13827038 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | (3-bromophenoxy)acetic acid | HCID 702285 | 98.5% |
Reaction Steps
At 0° C., lithium hydroxide monohydrate (8.41 g, 0.2 mol) is added to a solution of methyl 3-bromophenoxyacetate (19.66 g, 80 mmol) in solution in 100 ml of a water-THF mixture (3:1). Agitation is continued for 15 minutes at 0° C. and then the mixture is acidified by a 3N aqueous solution of hydrochloric acid. It is extracted with ether, dried over MgSO4, filtered and evaporated. 18.21 g of 3-bromophenoxyacetic acid is obtained (yield=98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06239284B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-ac9c8445c1b147b08c0517fc6cfaf766 |
| Source note | uspto-grants-2001_05 |