1,2-Dimethylhydrazine → HCID 54498128, compound

Participants

Reaction Steps

A stirred suspension of 4-(4′-chloro-biphenyl-4-yl)-4-oxo-butyric acid (0.578 g, 0.00200 mol) in a solution of dimethylhydrazine (0.46 mL, 0.0061 mol) in absolute ethanol (6 mL) was refluxed under nitrogen for 2.4 hours and allowed to cool. The volatiles were rotary evaporated, and the residue dissolved (CH2Cl2) and purified by column chromatography on silica gel, eluting with dichloromethane-methanol (24:1) to give 0.33 g of 4-(4′-chloro-biphenyl-4-yl)-4-(dimethylhydrazono)-butyric acid as a yellow solid; mp 158-160° C.

Provenance & Evidence