HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86583516, compound → 4-(2'-Fluoro-4'-chloro-4-biphenylyl)-4-oxo-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86583516 | HCID 86583516 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 4-(2'-Fluoro-4'-chloro-4-biphenylyl)-4-oxo-butyric acid | HCID 18364124 | 91.9% |
Reaction Steps
In a manner similar to Example 4, Step (b), 4-(4′-chloro-2′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester (1.39 g, 0.00433 mol) was refluxed in 6 M hydrochloric acid to give 1.22 g of 4-(4′-chloro-2′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid as a light purple solid; mp 127-129° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06239288B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-e6f5977dd5004ca388bcac1718cca77e |
| Source note | uspto-grants-2001_05 |