HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluorobiphenyl → 4-(2'-Fluoro-biphenyl-4-yl)-4-oxo-butyric acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluorobiphenyl | HCID 67579 | — |
| Reactant | Butanoic acid, 4-chloro-4-oxo-, methyl ester | HCID 73888 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(2'-Fluoro-biphenyl-4-yl)-4-oxo-butyric acid methyl ester | HCID 21491867 | — |
Reaction Steps
In a manner similar to Example 2, Step (a), 2-fluoro-biphenyl (6.284 g, 0.0365 mol) was allowed to react with 3-carbomethoxypropionyl chloride (4.95 mL, 0.0402 mol) in the presence of anhydrous aluminum chloride (10.7 g, 0.0802 mol) in dichloromethane to give, after chromatography on silica gel (456 g, 230-400 mesh), eluting with chloroform (15×450 mL), 7.36 g of 4-(2′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester as a pale yellow solid; mp 75.5-77.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06239288B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-2ee11c0735144ad18ae16e6a8d0b0adf |
| Source note | uspto-grants-2001_05 |