HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 4-(2'-Fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 3-[4-(2-Fluorophenyl)benzoyl]propanoic acid | HCID 13758270 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(2'-Fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid | HCID 73432321 | 83.2% |
Reaction Steps
In a manner similar to Example 4, Step (c), 4-(2′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid (1.634 g, 0.006001 mol) was allowed to react with hydroxylamine hydrochloride (0.500 g, 0.00720 mol) in the presence of sodium carbonate (0.763 g, 0.00720 mol) in absolute ethanol to give 1.434 g of 4-(2′-fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid as a pale yellow solid; mp 150.0-151.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06239288B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-ca620faadb364ad68c71060f343b644e |
| Source note | uspto-grants-2001_05 |