HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 4-Hydroxyimino-4-(4'-methyl-biphenyl-4-yl)-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 4-(4'-Methyl-biphenyl-4-yl)-4-oxo-butyric acid | HCID 14116666 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Hydroxyimino-4-(4'-methyl-biphenyl-4-yl)-butyric acid | HCID 85049784 | 90.5% |
Reaction Steps
In a manner similar to Example 4, Step (c), 4-(4′-methyl-biphenyl-4-yl)-4-oxo-butyric acid (1.052 g, 0.003922 mol) was allowed to react with hydroxylamine hydrochloride (0.3245 g, 0.00467 mol) in the presence of sodium carbonate (0.498 g, 0.00470 mol) in absolute ethanol to give 1.006 g of 4-hydroxyimino-4-(4′-methyl-biphenyl-4-yl)-butyric acid as a white solid; mp 176.5-177.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06239288B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-c0a3e19d43be432a9098d4d76288b8c0 |
| Source note | uspto-grants-2001_05 |