Hydrochloric Acid → HCID 86756867, compound

Participants

Reaction Steps

A solution of 0.656 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-2′-(N-tert.-butoxycarbonyl-D-prolyl)-4-methylvalerohydrazide in 8 ml of dioxan was treated with 4 ml of 4M hydrogen chloride in dioxan. The mixture was stirred for 2 hours at room temperature and diluted with diethyl ether. The solid was filtered off, washed with diethyl ether and dried to give 0.367 g of (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-isobutyl-2′-(D-prolyl)-4-methylvalerohydrazide hydrochloride in the form of a white solid.

Provenance & Evidence