p-Toluenesulfonic acid → HCID 86756871, compound

Participants

Reaction Steps

A solution of 0.38 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-2′-(O-tert.butyl-D-seryl)-4-methylvalerohydrazide in 5 ml of methanol was treated with 0.144 g of p-toluenesulphonic acid. The mixture was stirred for 3.5 hours at room temperature and evaporated to give a solid. This was triturated with diethyl ether, filtered off and dried to give 0.38 g of (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-isobutyl-2′-(O-tert.butyl-D-seryl)-4-methylvalerohydrazide p-toluenesulphonate in the form of a white solid.

Provenance & Evidence