HCID 86756874, compound → HCID 86756873, compound

Participants

Reaction Steps

A solution of 0.86 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-2′-[N-(9-fluorenylmethyloxycarbonyl)-O-tert.butyl-D-seryl]-4-methylvalerohydrazide in a mixture of 8 ml of dichloromethane and 2 ml of piperidine was stirred at room temperature for 3 hours. The solution was evaporated and the residue was treated with diethyl ether. The ethereal solution was filtered and evaporated. Chromatography on silica gel using methanol/dichloromethane (1:19) for the elution followed by evaporation gave 0.39 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-2′-(O-tert.butyl-D-seryl)-4-methylvalerohydrazide in the form of a gum.

Provenance & Evidence