p-Toluenesulfonic acid → (E)-2'-[(1-amino-1-cyclopentyl)carbonyl]-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2'-isobutyl-4-methylvalerohydrazide p-toluenesulphonate

Participants

Reaction Steps

A solution of 0.35 g of (E)-2′-[(1-amino-1-cyclopentyl)carbonyl]-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]4-phenyl-3-butenyl]-2′-isobutyl-4-methylvalerohydrazide in 3 ml of methanol was treated with 0.14 g of p-toluenesulphonic acid. The mixture was stirred for 1.7 hours at room temperature and evaporated to give a foam. This foam was triturated with diethyl ether, filtered off and dried to give 0.32 g of (E)-2′-[(1-amino-1-cyclopentyl)carbonyl]-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-isobutyl-4-methylvalerohydrazide p-toluenesulphonate in the form of a white solid.

Provenance & Evidence