Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2'-isobutyl-4-methyl-2'-(2-ureidoacetyl)valerohydrazide → (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2'-isobutyl-4-methyl-2'-(2-ureidoacetyl)valerohydrazide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2'-isobutyl-4-methyl-2'-(2-ureidoacetyl)valerohydrazide | HCID 86756885 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2'-isobutyl-4-methyl-2'-(2-ureidoacetyl)valerohydrazide | HCID 86756884 | 83.1% |
반응 단계
A solution of 0.51 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-(2-ureidoacetyl)valerohydrazide dissolved in 5 ml of 4M hydrogen chloride in dioxan was stirred for 2 hours at room temperature and diluted with diethyl ether. The solid was filtered off, washed with diethyl ether and dried to give 0.36 g of (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-(2-ureidoacetyl)valerohydrazide in the form of a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06239151B1 |
| 출처 데이터셋 | uspto-grants-2001_05 |
| ORD ID | ord-384a24952f444a13983b8f820b66bae7 |
| 출처 메모 | uspto-grants-2001_05 |