p-Toluenesulfonic acid → HCID 86756888, compound

Participants

Reaction Steps

A solution of 0.71 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-(2(RS)-hydroxypropionyl)-2′-isobutyl-4-methylvalerohydrazide in 8 ml of methanol was treated with 0.071 g of p-toluenesulphonic acid. The mixture was stirred for 1 hour at room temperature and evaporated to give a foam. This foam was triturated with diethyl ether, filtered off and dried to give 0.425 g of (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-(2(RS)-hydroxypropionyl)-2′-isobutyl-4-methylvalerohydrazide in the form of a white solid.

Provenance & Evidence