Diethyl Ether → HCID 86756889, compound

Participants

Reaction Steps

A solution of 1.11 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-(2(RS)-acetoxypropionyl)-2′-isobutyl-4-methylvalerohydrazide in a mixture of 8 ml of methanol and 4 ml of water was treated with 0.524 g of potassium carbonate. The mixture was stirred at room temperature for 2 hours, diluted with water and extracted with ethyl acetate. The ethyl acetate solution was washed with water, dried over anhydrous magnesium sulphate and was evaporated to give a foam. Trituration of this foam with diethyl ether gave 0.71 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-(2(RS)-hydroxypropionyl)-2′-isobutyl-4-methylvalerohydrazide in the form of a white solid.

Provenance & Evidence