p-Toluenesulfonic acid → HCID 86756891, compound

Participants

Reaction Steps

A solution of 0.175 g (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-(D-seryl)valerohydrazide in 2 ml of methanol was treated with 0.073 g of p-toluenesulphonic acid. The mixture was stirred for 3 hours at room temperature and evaporated. The residue was triturated with diethyl ether, filtered off and dried to give 0.160 g of (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-(D-seryl)valerohydrazide p-toluenesulphonate in the form of a white solid.

Provenance & Evidence