p-Toluenesulfonic acid → HCID 86756896, compound

Participants

Reaction Steps

A solution of 2.12 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-(2(R)-hydroxypropionyl)-2′-isobutyl-4-methylvalerohydrazide in 20 ml of methanol was treated with 0.212 g of p-toluenesulphonic acid. The mixture was stirred for 0.5 hour at room temperature and evaporated to give a foam. This foam in ethyl acetate was washed with 5% sodium hydrogen carbonate solution and water, dried over anhydrous magnesium sulphate and evaporated to low volume. The solid which separated was washed with cold ethyl acetate and dried to give 1.584 g of (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-(2(R)-hydroxypropionyl)-2′-isobutyl-4-methylvalerohydrazide in the form of a white solid.

Provenance & Evidence