Diethyl Ether → HCID 86756897, compound

Participants

Reaction Steps

A solution of 2.77 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-(2(R)-acetoxypropionyl)-2′-isobutyl-4-methylvalerohydrazide in a mixture of 20 ml of methanol and 10 ml of water was treated with 1.35 g of potassium carbonate. The mixture was stirred at room temperature for 2 hours, diluted with water and extracted with ethyl acetate. The ethyl acetate phase was washed with water, dried over anhydrous magnesium sulphate and evaporated to give a foam. Trituration of this foam with diethyl ether gave 2.12 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-(2(R)-hydroxypropionyl)-2′-isobutyl-4-methylvalerohydrazide in the form of a white solid.

Provenance & Evidence