N,N-Dimethylglycine → HCID 86756903, compound

Participants

Reaction Steps

A solution of 0.155 g of N,N-dimethylglycine in 10 ml of dimethylformamide was treated in sequence with 0.167 ml of N-ethylmorpholine, 0.216 g of 1-hydroxybenzotriazole and 0.307 g of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride. Stirring was continued for 1 hour at room temperature and then 0.459 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-4-methylvalerohydrazide was added. Stirring was continued overnight and then the mixture was diluted with ethyl acetate and washed in sequence with 5% aqueous sodium hydrogen carbonate and brine. Drying over magnesium sulphate and evaporation gave 0.591 g of (E)-2(R)-[1(S)-(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-[2-(dimethylamino)acetyl]valerohydrazide in the form of a white solid.

Provenance & Evidence